Gonorrhea

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[edit] Gonorrhea

Introduction:

This form of VD is caused by Neisseria gonorrhea, a Gram negative intracellular bacterium, which tends to grow in pairs of two ("diplococci"). It is a fulminant form of venereal disease and wherever it grows, it is very destructive. Most of the time gonorrhea is a local sexually transmitted disease.

However, when it is neglected, it can get spread, in which case it can lead to a high fever with septicemia, joint involvement and occasionally also meningitis, pericarditis or endocarditis.

Gonorrhea

Introduction

Signs and symptoms

Diagnostic tests

Treatment

This is called disseminated gonococcal infection (DGI).

Signs and symptoms:

In most cases the infection is affecting the genitals directly. In men the incubation time is 2 days to 2 weeks. There is a discomfort in the urethra, which is followed just hours later with dysuria (painful urination) and a pussy yellow discharge. Urination is now frequent and he has to go when he has to go (called "urgency").

The examining physician will see redness of the opening of the urethra on the glans of the penis with pus in the small pocket behind the outside opening ("meatus") of the urethra.

In women the disease is more varied. The incubation time after exposure is 1 to 3 weeks. It can be milder with only a mild burning with urination and a slight vaginal discharge. Or it can start with severe pain on urination, urinary frequency and vaginal discharge. The doctor finds on pelvic speculum examination that there is a lot of pus coming from the cervix, which is infected. On pelvic examination it is evident that quite often there is a fulminant infection in the fallopian tube on one or both sides. This is often the cause for infertility later down the road when the infection has been cured. The infection with Neisseria gonorrhea leaves scarring behind wherever it leads to inflammation and this is why the fallopian tubes are glued to the ovaries when the pelvic inflammatory disease (=PID or salpingitis, the arrow pointing to it) has occurred.

The eyes can get a severe conjunctivitis with a pussy discharge, which can lead to blindness, if not treated aggressively.

With disseminated gonococcal infection (DGI) there are other clinical signs of disease, for which the physician looks out such as joint swelling and tenderness with joint involvement (gonococcal arthritis); changed heart contours,heart sounds and murmurs with pericarditis or endocarditis; neck stiffness and change of mentation with meningitis; high fever and shock with septicemia.

Diagnostic tests:

In men Gram staining of smears from the meatus of the urethra will show the characteristic Gram negative double cocci(=diplococcus) inside cells in more than 90% of cases. In women using the same technique of smears from cervical secretions will only be positive in roughly 60%. The negative cases in both sexes need to be cultured or tested using genetic gonococcal RNA probing methods. Blood cultures would be wise to get in any more seriously sick patient to rule out septicemia with DGI. In newborns of women with active gonorrhea eye infections have to be ruled out by cultures and prophylactic treatment is given.

Treatment:

Any treatment must take into consideration that chlamydia infections are often coexisting with gonorrhea.

As well, drug resistance of Neisseria gonorrhea against penicillin and tetracycline has radically changed the previously ussed treatment schedules. The presently recommended regimen is to give ceftriaxone 125 mg intramuscularly once for gonorrhea and to combine this with doxycyline 100 mg twice per day for 7 days to cover for chlamydia. There are other regimens involving spectinomycin , ciprofloxacin, ofloxacin or cefixime.

For disseminated gonococcal infection (DGI) higher doses of ceftriaxone are needed ( 1 gram intramuscularly or intravenously daily) until the infection is gone, often 3 to 7 days. Alternatives are cefotaxime or ceftizoxime. Usually the patient with this disseminated form of gonorrhea is hospitalized and an infection specialist will direct treatment.

Infections overview

STD's

References:

1.The Merck Manual, 7^th edition, by M. H. Beers et al., Whitehouse Station, N.J., 1999. Chapter 163.

2.James Chin et al., Editors: Control of Communicable Diseases Manual, 17th edition, 2000, American Public Health Association.

3.The Merck Manual, 7^th edition, by M. H. Beers et al., Whitehouse Station, N.J., 1999. Chapter 164.

4. Feldman: Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 7th ed., © 2002 Elsevier : pages 1306-1307.

5. David L. Heymann,MD, Editor: Control of Communicable Diseases Manual, 18th edition, 2004, American Public Health Association.