Adult – AUL

What is acute undifferentiated leukemia (AUL) in adults?

AUL is a type of acute adult leukemia that is much less common than ALL and AML. It is characterized by a high number of immature bone marrow cells present in the patient.

What are the signs and symptoms of AUL?

Signs and symptoms of AUL are tied to the presence of anemia. The signs and symptoms include:
• Weakness;
• Fatigue;
• Pale skin;
• Infections;
• Frequent bleeding; and
• Minor bumps on skin leading to hematoma (swelling).

How is AUL diagnosed?

The diagnosis of AUL is made by way of exclusion. It is likely that a patient has AUL if they are not diagnosed with ALL or AML. To confirm the presence of leukemia, the physician will order a leukemia blood test with a blood smear.
The patient will be referred to a hematologist (blood specialist) to have a bone marrow aspirate and/or a bone marrow biopsy to make the final diagnosis of AUL.

How is AUL treated?

Combination chemotherapy is usually used to suppress the leukemia. Platelet transfusions and blood transfusions may also have to be given for a period of time. Bone marrow transplantation may be considered. In case of infections antibiotic therapy may have to be given as well.

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